[HTML][HTML] Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome
The rising rates of obesity worldwide have increased the incidence of cardiovascular
disease (CVD), making it the number one cause of death. Higher plasma bilirubin levels …
disease (CVD), making it the number one cause of death. Higher plasma bilirubin levels …
Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics
WH Lee, ZA Kipp, SN Pauss, GJ Martinez… - Clinical …, 2025 - portlandpress.com
Metabolic and insulin-resistant diseases, such as type 2 diabetes mellitus (T2DM), have
become major health issues worldwide. The prevalence of insulin resistance in the general …
become major health issues worldwide. The prevalence of insulin resistance in the general …
[HTML][HTML] Adipose mesenchymal stem cell-derived extracellular vesicles alleviate renal fibrosis by reducing epithelial-mesenchymal transition via the FOXS1/Wnt/β …
J Sun, Y Jia, Y Bian, H Liang, X Du - International Immunopharmacology, 2025 - Elsevier
Background Adipose mesenchymal stem cells (ADSCs) exert beneficial effects on kidney
disease through a paracrine mechanism. However, the specific molecular mechanisms by …
disease through a paracrine mechanism. However, the specific molecular mechanisms by …
Glucocorticoid Resistance Remodels Liver Lipids and Prompts Lipogenesis, Eicosanoid, and Inflammatory Pathways
GJ Martinez, ZA Kipp, WH Lee, EA Bates… - Prostaglandins & Other …, 2024 - Elsevier
We have previously demonstrated that the glucocorticoid receptor β (GRβ) isoform induces
hepatic steatosis in mice fed a normal chow diet. The GRβ isoform inhibits the glucocorticoid …
hepatic steatosis in mice fed a normal chow diet. The GRβ isoform inhibits the glucocorticoid …
Unique and Shared Molecular Mechanisms of Alcoholic and Non-Alcoholic Liver Cirrhosis Identified Through Transcriptomics Data Integration
KH Park, H Lee, JH Lee, DK Yon, YI Choi… - OMICS: A Journal of …, 2024 - liebertpub.com
Liver cirrhosis is a severe chronic disease that results from various etiological factors and
leads to substantial morbidity and mortality. Alcoholic cirrhosis (AC) and non-AC (NAC) arise …
leads to substantial morbidity and mortality. Alcoholic cirrhosis (AC) and non-AC (NAC) arise …
LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis
Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis,
which is characterized by increased collagen production by activated Hepatic Stellate Cells …
which is characterized by increased collagen production by activated Hepatic Stellate Cells …
THE FUNCTION OF THE INSULIN RECEPTOR IN LIVER SUBCELL TYPES AND ITS DICHOTOMOUS ROLE IN HEPATIC DYSFUNCTION
WH Lee - uknowledge.uky.edu
Insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD)
have become significant health issues worldwide. Increased prevalence of hepatic insulin …
have become significant health issues worldwide. Increased prevalence of hepatic insulin …