Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem
cells and blood production. To protect against aldehydes, mammals have evolved a family of …

Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi
anemia, glucose-6-phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The …

Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a
deficiency in repairing DNA crosslinks, which are known to perturb several cellular …

Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …

Once thought to be exceedingly rare, the advent of next-generation sequencing has
revealed a plethora of germline predisposition disorders that confer risk for hematopoietic …

Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important
endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion …

As one of the most basic substances in the live system, the improper regulation of nucleic
acid behavior may cause cell dysfunction and induce serious diseases. As the main storage …

Abstract Aldehyde dehydrogenase 2 (ALDH2) deficiency caused by genetic variant is
present in more than 560 million people of East Asian descent, which can be identified by …

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Although hematopoietic stem cells (HSCs) in the bone marrow are in a state of quiescence,
they harbor the self-renewal capacity and the pluripotency to differentiate into mature blood …