Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

Introduction: Glycogen synthase kinase 3 (GSK3) is at the center of cellular signaling and
controls various aspects of brain functions, including development of the nervous system …

Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound
present in the Cannabis sativa plant, attenuate the anxiogenic effects induced by Chronic …

Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …

Thiamine (vitamin B1) is essential for brain function because of the coenzyme role of
thiamine diphosphate (ThDP) in glucose and energy metabolism. In order to compensate …

Circadian modulation of learning and memory efficiency is an evolutionarily conserved
phenomenon, occurring in organisms ranging from invertebrates to higher mammalian …

Objective Chaihu Shugan San (CSS) is a common antidepressant prescription in traditional
Chinese medicines. However, its active ingredients and mechanisms are unknown. The aim …

Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of
glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell …

Recent findings of potential implications of glycogen synthase kinase-3β (GSK-3β)
dysfunction in psychiatric disorders like depression, have increased focus for development …

Signaling mediated by brain-derived neurotrophic factor (BDNF), which is supported by the
postsynaptic scaffolding protein PSD-95, has antidepressant effects. Conversely, clinical …