Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Two concepts for the long-term regulation of arterial pressure were considered in this
review, the neural control hypothesis and the volume regulation hypothesis. The role of the …

The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways …

Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …

The endothelium not only mediates relaxation but is a source of contracting factors.
Endothelium-dependent contractions are elicited by physical and chemical stimuli (ie …

The membrane-bound endogenous fatty acid arachidonic acid can be released from
membranes by phospholipases and then metabolized to biologically active compounds by …

Mechanical forces generated at the endothelium by fluid shear stress and pulsatile stretch
are important in ensuring the continuous release of vasoactive endothelial autacoids …

Hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE) is a cytochrome P450 (CYP)–derived
omega-hydroxylation metabolite of arachidonic acid. 20-HETE has been shown to play a …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …