The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

Cell division is enacted by a microtubule-based, self-assembling macromolecular machine
known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

The small GTPase Ran regulates the interaction of transport receptors with a number of
cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import …

The unexpected repurposing of nuclear transport proteins from their function in interphase to
an equally vital and very different set of functions in mitosis was very surprising. The multi …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …

Organisms with closed or open mitosis have differentially evolved various gamma-tubulin
complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays …