Chronotropic incompetence (CI), broadly defined as the inability of the heart to increase its
rate commensurate with increased activity or demand, is common in patients with …

Chronotropic incompetence (CI) is generally defined as the inability to increase the heart
rate (HR) adequately during exercise to match cardiac output to metabolic demands. In …

Aims We hypothesized that nebivolol, a beta‐blocker with nitric oxide‐releasing properties,
could favourably affect exercise capacity in patients with heart failure and preserved left …

Heart rate (HR) responds to exercise by increasing during exercise and recovering after
exercise. As such, HR is an important predictor of mortality that researchers believe is …

Aims Predicting maximal heart rate (MHR) in heart failure with reduced ejection fraction
(HFrEF) still remains a major concern. In such a context, the Keteyian equation is the only …

Heart failure (HF) represents a leading cause of morbidity and mortality. However, HF trials
highlighted many differences between men and women with HF. Thus, women represent …

Cardiovascular risk of increased heart rate (HR) was first reported in the Framingham study.
Thereafter, the risk of increased HR for mortality has been extensively studied, suggesting …

Objectives: The purpose of this study was to compare the prognostic impact of clinical and
biomarker correlates of resting heart rate (HR) and chronotropic incompetence in heart …

Aim: To assess the effect of chronotropic incompetence on functional capacity in chronic
heart failure (CHF) patients, as evaluated as NYHA and peak oxygen consumption (pVO2) …

Aims An independent role for the exercise‐induced heart rate (HR) response—and
specifically the chronotropic incompetence (CI)—in the prognosis of heart failure (HF) is still …