Ezetimibe attenuates oxidative stress and neuroinflammation via the AMPK/Nrf2/TXNIP pathway after MCAO in rats

J Yu, W Wang, N Matei, X Li, J Pang… - Oxidative Medicine …, 2020 - Wiley Online Library
Oxidative stress and neuroinflammation play essential roles in ischemic stroke‐induced
brain injury. Previous studies have reported that Ezetimibe (Eze) exerts antioxidative stress …

Lipids, blood pressure and kidney update 2015

M Banach, WS Aronow, MC Serban, J Rysz… - Lipids in health and …, 2015 - Springer
The most important studies and guidelines in the topics of lipid, blood pressure and kidney
published in 2015 were reviewed. In lipid research, the IMProved Reduction of Outcomes …

[HTML][HTML] Quercetin protects against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress

R Huang, T Zhong, H Wu - Archives of medical science: AMS, 2015 - ncbi.nlm.nih.gov
Results The LPS treatment led to increased alveolar wall thickening and cellular infiltration
in the lung, which was markedly prevented by quercetin pretreatment. Moreover, quercetin …

Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats

J Yu, X Li, N Matei, D McBride, J Tang, M Yan… - Experimental …, 2018 - Elsevier
Autophagy activation exerts neuroprotective effects in the ischemic stroke model. Ezetimibe
(Eze), a Niemann–Pick disease type C1-Like 1 (NPC1L1) pharmacological inhibitor, has …

[PDF][PDF] Antiobesity, hypolipidemic, antioxidant and hepatoprotective effects of Achyranthes aspera seed saponins in high cholesterol fed albino rats

N Khan, MS Akhtar, BA Khan… - Archives of medical …, 2015 - termedia.pl
Results: Four-week oral administration of A. aspera seed saponins produced a significant
(p< 0.05) decrease of total cholesterol, total triglycerides and LDL-C and a significant …

Ezetimibe alleviates acetic acid-induced ulcerative colitis in rats: targeting the Akt/NF-κB/STAT3/CXCL10 signaling axis

RE Mostafa, RF Abdel-Rahman - Journal of Pharmacy and …, 2023 - academic.oup.com
Objective Ulcerative colitis (UC) is a relapsing inflammatory health state posing significant
worldwide problems. Ezetimibe is a cholesterol-lowering drug having anti-inflammatory and …

Ezetimibe ketone protects against renal ischemia–reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO‐1 signaling pathway

Z Chen, K Wang, X He, D Xue… - Journal of Biochemical …, 2024 - Wiley Online Library
Recently, ezetimibe (EZM) has been suggested to be a potent Nrf2 activator that is important
for preventing oxidative stress. Interestingly, we found that its metabolite ezetimibe ketone …

Ezetimibe attenuates functional impairment via inhibition of oxidative stress and inflammation in traumatic spinal cord injury

W Rong, H Li, H Yang, B Yuan, J Zhu… - Cellular and Molecular …, 2023 - cellmolbiol.org
Sustained inflammation after a traumatic spinal cord injury (TSCI) triggers oxidative stress
and neuronal apoptosis, hindering functional recovery. Ezetimibe (EZE) has been reported …

[PDF][PDF] The vitamin D analogue paricalcitol attenuates hepatic ischemia/reperfusion injury through down-regulation of Toll-like receptor 4 signaling in rats

MS Kim, S Lee, N Jung, K Lee, J Choi, SH Kim… - Archives of Medical …, 2017 - termedia.pl
Results: Liver damage following I/R was diminished by pretreatment with paricalcitol.
Pretreatment with paricalcitol decreased the levels of pro-inflammatory mediators, such as …

[PDF][PDF] Inducible and endothelial nitric oxide synthase distribution and expression with hind limb per-conditioning of the rat kidney

Z Sedaghat, M Kadkhodaee, B Seifi… - Archives of Medical …, 2019 - termedia.pl
Results The protective effect of RPEC on renal function, oxidative stress indices, pro-
inflammatory marker expression and histopathological changes of kidneys subjected to 45 …