The spermatozoon is a highly differentiated cell with unique characteristics: it is mobile,
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …

Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through
somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian …

Infertility has been reported as one of the most common reproductive impairments, affecting
nearly one in six couples worldwide. A large proportion of infertility cases are diagnosed as …

In mammals, sperm-borne regulators can be transferred to oocytes during fertilization and
have different effects on the formation of pronuclei, the first cleavage of zygotes, the …

Accumulating evidence indicates that paternally derived microRNAs play a crucial role in the
development of early embryos and are regarded as the key factor in the successful …

Simple Summary Genetically modified farm animals have been actively used in a number of
applications from testing gene functions to increasing production and economic value of …

In brief Almost total lack of sperm-borne RNAs is regarded as one of the key factors that
leads to the abnormal development of somatic cell nuclear transfer embryo. This paper …

Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of
transgenic animals, protection of endangered animals, and therapeutic cloning. However …

The study's objectives were to examine the effects of electrofusion on rabbit somatic cell
nuclear transfer (SCNT) embryos, and to test melatonin as a protective agent against …

The low efficiency of somatic cell nuclear transfer (SCNT) greatly limits its application.
Compared with the fertilized embryo, cloned embryos display abnormal epigenetic …