Causes, consequences, and treatment of metabolically unhealthy fat distribution

N Stefan - The lancet Diabetes & endocrinology, 2020 - thelancet.com
An increase in fat mass is considered to be an important risk factor for the worldwide
increase in type 2 diabetes and cardiovascular disease. However, for a given fat mass, there …

HIV infection and cardiovascular disease

LG Hemkens, HC Bucher - European heart journal, 2014 - academic.oup.com
Aims With the success of antiretroviral therapy (ART), non-human immunodeficiency virus
(HIV)-related comorbidities like cardiovascular diseases (CVDs) are of increasing concern …

Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised …

J Lo, MT Lu, EJ Ihenachor, J Wei, SE Looby… - The lancet HIV, 2015 - thelancet.com
Background HIV-infected patients have a high risk of myocardial infarction. We aimed to
assess the ability of statin treatment to reduce arterial inflammation and achieve regression …

Pathogenesis and diagnosis of growth hormone deficiency in adults

S Melmed - New England Journal of Medicine, 2019 - Mass Medical Soc
Growth Hormone Assessment in Adults Growth hormone synthesis and physiology are
discussed in the context of recombinant growth hormone use in adults. Growth hormone …

Lipodystrophy: pathophysiology and advances in treatment

CG Fiorenza, SH Chou, CS Mantzoros - Nature Reviews Endocrinology, 2011 - nature.com
Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …

The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations

DE Berryman, CAM Glad, EO List… - Nature Reviews …, 2013 - nature.com
Obesity has become one of the most common medical problems in developed countries,
and this disorder is associated with high incidences of hypertension, dyslipidaemia …

Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial

TL Stanley, MN Feldpausch, J Oh, KL Branch, H Lee… - Jama, 2014 - jamanetwork.com
Importance Among patients infected with human immunodeficiency virus (HIV), visceral
adiposity is associated with metabolic dysregulation and ectopic fat accumulation …

Severe insulin resistance syndromes

AM Angelidi, A Filippaios… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Severe insulin resistance syndromes are a heterogeneous group of rare disorders
characterized by profound insulin resistance, substantial metabolic abnormalities, and a …

Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled …

J Falutz, JC Mamputu, D Potvin, G Moyle… - The Journal of …, 2010 - academic.oup.com
Context: HIV patients treated with antiretroviral therapy (ART) often develop increased
visceral adipose tissue (VAT). Objective: Our objective was to perform a pooled analysis of …

Management of the metabolic effects of HIV and HIV drugs

TT Brown, MJ Glesby - Nature reviews endocrinology, 2012 - nature.com
Morphologic and metabolic abnormalities, including subcutaneous adipose tissue wasting,
central adipose tissue accumulation, dyslipidemia and disorders of glucose metabolism are …