Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

Background Understanding the dynamic cellular behaviors and underlying molecular
mechanisms that drive morphogenesis is an ongoing challenge in biology. Live imaging …

During testis development, the rapid morphological changes initiated by Sry require the
coordinate integration of many signaling pathways. Based on the established role of the …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

In mammals, female development has traditionally been considered a default process in the
absence of the testis-determining gene, Sry. Recently, it has been documented that the gene …

The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

Context: The human adrenal zona fasciculata (ZF) and zona reticularis (ZR) are responsible
for the production of cortisol and 19-carbon steroids (often called adrenal androgens) …

Abstract Wnt4‐/‐XX gonads display features normally associated with testis differentiation,
suggesting that WNT4 actively represses elements of the male pathway during ovarian …