Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy

FA Lévi, A Okyar, E Hadadi… - Annual review of …, 2024 - annualreviews.org
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Histopathological characterization of radiofrequency ablation in ventricular scar tissue

M Barkagan, E Leshem, A Shapira-Daniels… - JACC: Clinical …, 2019 - jacc.org
Objectives: This study sought to characterize the histopathological features of
radiofrequency ablation (RFA) in heterogeneous ventricular scar in comparison to those in …

In vivo pulsed-field ablation in healthy vs. chronically infarcted ventricular myocardium: biophysical and histologic characterization

U Sandhu, L Alkukhun, B Kheiri, J Hodovan… - Europace, 2023 - academic.oup.com
Aims Data on ventricular pulsed-field ablation (PFA) are sparse in the setting of chronic
myocardial infarction (MI). The objective of this study was to compare the biophysical and …

First clinical use of novel ablation catheter incorporating local impedance data

CA Martin, R Martin, PR Gajendragadkar… - Journal of …, 2018 - Wiley Online Library
Introduction Successful catheter ablation is limited by both poor spatial resolution of
abnormal local signals and inability to deliver an effective lesion due to poor tissue contact …

Lipomatous metaplasia enables ventricular tachycardia by reducing current loss within the protected corridor

L Xu, M Khoshknab, RD Berger, J Chrispin… - Clinical …, 2022 - jacc.org
Background Post–myocardial infarction ventricular tachycardia (VT) is due to re-entry
through surviving conductive myocardial corridors across infarcted tissue. However, not all …

Ablation lesion characterization in scarred substrate assessed using cardiac magnetic resonance

S Tao, MA Guttman, S Fink, H Elahi, KD Patil… - JACC: Clinical …, 2019 - jacc.org
Objectives: This study examined radiofrequency catheter ablation (RFCA) lesions within and
around scar by cardiac magnetic resonance (CMR) imaging and histology. Background …

Nanoengineered sprayable therapy for treating myocardial infarction

M Muñoz, C Eren Cimenci, K Goel, M Comtois-Bona… - ACS …, 2022 - ACS Publications
We report the development, as well as the in vitro and in vivo testing, of a sprayable
nanotherapeutic that uses surface engineered custom-designed multiarmed peptide grafted …

Mapping of ventricular tachycardia in patients with ischemic cardiomyopathy: Current approaches and future perspectives

C Pandozi, C Lavalle, M Russo, M Galeazzi… - Clinical …, 2019 - Wiley Online Library
Despite the technical improvements made in recent years, the overall long‐term success
rate of ventricular tachycardia (VT) ablation in patients with ischemic cardiomyopathy …

Local impedance guides catheter ablation in patients with ventricular tachycardia

P Münkler, MA Gunawardene, C Jungen… - Journal of …, 2020 - Wiley Online Library
Aims Catheter contact and local tissue characteristics are relevant information for successful
radiofrequency current (RFC)‐ablation. Local impedance (LI) has been shown to reflect …

Biophysics and electrophysiology of pulsed field ablation in normal and infarcted porcine cardiac ventricular tissue

D Miklavčič, A Verma, PRP Krahn, J Štublar, B Kos… - Scientific Reports, 2024 - nature.com
Abstract Pulsed Field Ablation (PFA) is a new ablation method being rapidly adopted for
treatment of atrial fibrillation, which shows advantages in safety and efficiency over …