Glial cells (astrocytes, oligodendrocytes and microglia) are critical for the central nervous
system (CNS) in both physiological and pathological conditions. With this in mind, several …

Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

The mammary epithelial cells (MECs) of high‐producing dairy cows are likely to be subject
to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study …

Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine, a guanine-based purine, is an extracellular signaling molecule that is released
from astrocytes and has been shown to promote central nervous system defenses in several …

Astrocytes are dynamic cells that maintain brain homeostasis by regulating neurotransmitter
systems, antioxidant defenses, inflammatory responses and energy metabolism. Astroglial …

Accumulating evidences indicate that endogenous modulators of excitatory synapses in the
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …

Stroke is the major cause of death and the most frequent cause of disability in the adult
population worldwide. Guanosine plays an important neuroprotective role in several …

The ketamine's potential for the treatment of refractory depression and anxiety has been
considered one the most important discoveries in the last years, however, repeated use of …