This review covers studies which exploit triazole-modified nucleic acids in the range of
chemistry and biology to medicine. The 1, 2, 3-triazole unit, which is obtained via click …

Herein, we proposed a terminal deoxynucleotidyl transferase (TdT), a potential biomarker of
lymphoid tumors, responsive fluorescence polarization (FP)-sensing protocol based on …

Triazole linkages (TLs) are mimics of the phosphodiester bond in oligonucleotides with
applications in synthetic biology and biotechnology. Here we report the RuAAC-catalyzed …

The use of RNA-seq as a generalized tool to measure the differential expression of genes
has essentially replaced the use of the microarray. Despite the acknowledged technical …

The ever-growing demand for inexpensive, rapid, and accurate exploration of genomes calls
for refinement of existing sequencing techniques. The development of next-generation …

Sequence-based characterization of bacterial communities has long been a hostage of
limitations of both 16S rRNA gene and whole metagenome sequencing. Neither approach is …

We report a chemical DNA–DNA ligation method based on copper-catalyzed azide–alkyne
cycloaddition (CuAAC). We demonstrate that ion addition dramatically influences the …

The modification of DNA or RNA backbones is an emerging technology for therapeutic
oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported …

An oligonucleotide of triazole‐linked RNA (TLRNA) was synthesized by performing
consecutive copper‐catalyzed azide‐alkyne cycloaddition reactions for elongation. The …

High-throughput RNA sequencing offers a comprehensive analysis of transcriptome
complexity originated from regulatory events, such as differential gene expression …