[HTML][HTML] Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives

SJ Gasparini, S Llonch, O Borsch, M Ader - Progress in retinal and eye …, 2019 - Elsevier
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Stem cell therapy for retinal degeneration: the evidence to date

A Sharma, BG Jaganathan - Biologics: Targets and Therapy, 2021 - Taylor & Francis
There is a rise in the number of people who have vision loss due to retinal diseases, and
conventional therapies for treating retinal degeneration fail to repair and regenerate the …

Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

RA Pearson, A Gonzalez-Cordero, EL West… - Nature …, 2016 - nature.com
Photoreceptor replacement by transplantation is proposed as a treatment for blindness.
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …

Restoration of vision after transplantation of photoreceptors

RA Pearson, AC Barber, M Rizzi, C Hippert, T Xue… - Nature, 2012 - nature.com
Cell transplantation is a potential strategy for treating blindness caused by the loss of
photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult …

Intelligent image-based deformation-assisted cell sorting with molecular specificity

AA Nawaz, M Urbanska, M Herbig, M Nötzel, M Kräter… - Nature …, 2020 - nature.com
Although label-free cell sorting is desirable for providing pristine cells for further analysis or
use, current approaches lack molecular specificity and speed. Here, we combine real-time …

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

A Gonzalez-Cordero, EL West, RA Pearson… - Nature …, 2013 - nature.com
Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy.
We previously demonstrated retinal repair and restoration of vision through transplantation …

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

MS Singh, J Balmer, AR Barnard, SA Aslam… - Nature …, 2016 - nature.com
Photoreceptor transplantation is a potential future treatment for blindness caused by retinal
degeneration. Photoreceptor transplantation restores visual responses in end-stage retinal …

Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange

T Santos-Ferreira, S Llonch, O Borsch, K Postel… - Nature …, 2016 - nature.com
Pre-clinical studies provided evidence for successful photoreceptor cell replacement
therapy. Migration and integration of donor photoreceptors into the retina has been …

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

MS Singh, P Charbel Issa, R Butler… - Proceedings of the …, 2013 - National Acad Sciences
One strategy to restore vision in retinitis pigmentosa and age-related macular degeneration
is cell replacement. Typically, patients lose vision when the outer retinal photoreceptor layer …

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

JR Soucy, EA Aguzzi, J Cho, MJ Gilhooley… - Molecular …, 2023 - Springer
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …