Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis
point to distinct immunological pathways that drive disease relapses and progression. In …

Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial
venous blood. Trm cells are heterogeneous but collectively constitute the most abundant …

Objective A novel autoimmune central nervous system (CNS) disorder with glial fibrillary
acidic protein (GFAP)‐IgG as biomarker was recently characterized. Here, 102 patients with …

Importance A novel astrocytic autoantibody has been identified as a biomarker of a
relapsing autoimmune meningoencephalomyelitis that is immunotherapy responsive …

Over the past decade, it has become clear that there is an important subset of memory T
cells that resides in tissues—tissue-resident memory T (TRM) cells. There is an emerging …

Resident memory T cells are non-recirculating memory T cells that persist long-term in
epithelial barrier tissues, including the gastrointestinal tract, lung, skin, and reproductive …

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system
(CNS) leading to the progressive destruction of the myelin sheath surrounding axons. It can …

Autoimmune glial fibrillary acidic protein astrocytopathy : Current Opinion in Neurology
Autoimmune glial fibrillary acidic protein astrocytopathy : Current Opinion in Neurology Log in or …

Following their activation and expansion in response to foreign threats, many T cells are
retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ …

Tissue resident memory T (TRM) cells reside in peripheral, non-lymphoid tissues such as
the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin TRM …