Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos,
which is essential for neuron function and survival. Deficits in lysosome function result in …

Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and
leads to progressive vision loss. The first pathological signs can be seen at the optic nerve …

In neurons, RNA granules are transported along the axon for local translation away from the
soma. Recent studies indicate that some of this transport involves hitchhiking of RNA …

Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It
functions as a~ 4-megadalton complex containing its cofactor dynactin and a cargo-specific …

Neurons, because of their elaborate morphology and the long distances between distal
axons and the soma as well as their longevity, pose special challenges to autophagy and to …

Axons are processes of neurons, up to a metre long, that form the essential biological cables
wiring nervous systems. They must survive, often far away from their cell bodies and up to a …

Most of the vesicular transport pathways inside the cell are facilitated by molecular motors
that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that …

The adaptor protein complex-4 or AP-4 is known to mediate autophagosome maturation
through regulating sorting of transmembrane cargo such as ATG9A at the Golgi. There is a …

The number of acquired or inherited conditions leading to axon degeneration (from now on
referred to as axonopathies) is vast. To diagnose patients, clinicians use a range of …

Blast-induced neurotrauma (BINT) is a pressing concern for veterans and civilians exposed
to explosive devices. Affected personnel may have increased risk for long-term cognitive …