Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells.
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-
producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is …

APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that
mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell …

Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance
of circulating autoantibodies to pancreatic islets. However, almost nothing is known about …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor
resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that …

Self-reactive T cells experience chronic antigen exposure but do not exhibit signs of
exhaustion. Here, we investigated the mechanisms for sustained, functioning autoimmune …

BACKGROUND. Neutrophils and their inflammatory mediators are key pathogenic
components in multiple autoimmune diseases, while their role in human type 1 diabetes …

Autoimmune diabetes is characterized by inflammatory infiltration; however, the initiating
events are poorly understood. We found that the islets of Langerhans in young nonobese …