The lactoferrin phenomenon—a miracle molecule

P Kowalczyk, K Kaczyńska, P Kleczkowska… - Molecules, 2022 - mdpi.com
Numerous harmful factors that affect the human body from birth to old age cause many
disturbances, eg, in the structure of the genome, inducing cell apoptosis and their …

[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery

H Gao - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease

M Wang, A Li, M Sekiya, ND Beckmann, X Quan… - Neuron, 2021 - cell.com
To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …

Human antimicrobial peptides as therapeutics for viral infections

A Ahmed, G Siman-Tov, G Hall, N Bhalla, A Narayanan - Viruses, 2019 - mdpi.com
Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

Lactoferrin in a context of inflammation-induced pathology

ML Kruzel, M Zimecki, JK Actor - Frontiers in immunology, 2017 - frontiersin.org
Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-
binding glycoprotein, in the milieu of immune functionality. This review represents a unique …

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

A Heintz-Buschart, P May, CC Laczny, LA Lebrun… - Nature …, 2016 - nature.com
The gastrointestinal microbiome is a complex ecosystem with functions that shape human
health. Studying the relationship between taxonomic alterations and functional …

Breast milk oligosaccharides: structure-function relationships in the neonate

JT Smilowitz, CB Lebrilla, DA Mills… - Annual review of …, 2014 - annualreviews.org
In addition to providing complete postnatal nutrition, breast milk is a complex biofluid that
delivers bioactive components for the growth and development of the intestinal and immune …

Lactoferrin as a natural immune modulator

JK Actor, SA Hwang, ML Kruzel - Current pharmaceutical …, 2009 - ingentaconnect.com
Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and
adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the …

A new age for iron: antitumoral ferrocenes

SS Braga, AMS Silva - Organometallics, 2013 - ACS Publications
From the core of the earth to the core of the archetypal organometallic compound ferrocene,
iron and its compounds contribute to create many aspects of our reality: the earth's …

[HTML][HTML] Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery

R Varela-Fernández, X García-Otero… - European Journal of …, 2022 - Elsevier
Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant
improvements in terms of high drug loading capacity and controlled drug release. The …