There is a constant high demand for energy to sustain the continuous contractile activity of the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …
S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc
Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …
Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
ED Abel, SE Litwin, G Sweeney - Physiological reviews, 2008 - journals.physiology.org
The dramatic increase in the prevalence of obesity and its strong association with cardiovascular disease have resulted in unprecedented interest in understanding the effects …
R Yang, LA Barouch - Circulation research, 2007 - Am Heart Assoc
Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on multiple organ systems. In this review, we summarize major leptin signaling pathways …
DD Adingupu, SO Göpel, J Grönros, M Behrendt… - Cardiovascular …, 2019 - Springer
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is the first class of anti- diabetes treatment that reduces mortality and risk for hospitalization due to heart failure. In …
B Wang, Q Yang, Y Sun, Y Xing, Y Wang… - Journal of cellular …, 2014 - Wiley Online Library
Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement in cardiac …
ZW Liu, HT Zhu, KL Chen, X Dong, J Wei, C Qiu… - Cardiovascular …, 2013 - Springer
Background Endoplasmic reticulum (ER) stress is considered one of the mechanisms contributing to reactive oxygen species (ROS)-mediated cell apoptosis. In diabetic …
DR Gonzalez, F Beigi, AV Treuer… - Proceedings of the …, 2007 - National Acad Sciences
Altered Ca2+ homeostasis is a salient feature of heart disease, where the calcium release channel ryanodine receptor (RyR) plays a major role. Accumulating data support the notion …