Endothelial dysfunction and diabetic cardiomyopathy

M Wang, Y Li, S Li, J Lv - Frontiers in Endocrinology, 2022 - frontiersin.org
The cardiovascular complications contribute to a majority of diabetes associated morbidity
and mortality, accounting for 44% of death in those patients with type 1 diabetes mellitus …

Myocardial fatty acid metabolism in health and disease

GD Lopaschuk, JR Ussher, CDL Folmes… - Physiological …, 2010 - journals.physiology.org
There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Diabetic cardiomyopathy revisited

S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc
Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

S-nitrosylation: an emerging paradigm of redox signaling

V Fernando, X Zheng, Y Walia, V Sharma, J Letson… - Antioxidants, 2019 - mdpi.com
Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …

Cardiac remodeling in obesity

ED Abel, SE Litwin, G Sweeney - Physiological reviews, 2008 - journals.physiology.org
The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Leptin signaling and obesity: cardiovascular consequences

R Yang, LA Barouch - Circulation research, 2007 - Am Heart Assoc
Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on
multiple organ systems. In this review, we summarize major leptin signaling pathways …

SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice

DD Adingupu, SO Göpel, J Grönros, M Behrendt… - Cardiovascular …, 2019 - Springer
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is the first class of anti-
diabetes treatment that reduces mortality and risk for hospitalization due to heart failure. In …

Resveratrol‐enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice

B Wang, Q Yang, Y Sun, Y Xing, Y Wang… - Journal of cellular …, 2014 - Wiley Online Library
Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect
on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement in cardiac …

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic …

ZW Liu, HT Zhu, KL Chen, X Dong, J Wei, C Qiu… - Cardiovascular …, 2013 - Springer
Background Endoplasmic reticulum (ER) stress is considered one of the mechanisms
contributing to reactive oxygen species (ROS)-mediated cell apoptosis. In diabetic …

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes

DR Gonzalez, F Beigi, AV Treuer… - Proceedings of the …, 2007 - National Acad Sciences
Altered Ca2+ homeostasis is a salient feature of heart disease, where the calcium release
channel ryanodine receptor (RyR) plays a major role. Accumulating data support the notion …