Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …

The small heat shock proteins (sHSPs) and the related α-crystallins (αCs) are virtually
ubiquitous proteins that are strongly induced by a variety of stresses, but that also function …

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with
poor renewal capacity, an integral reason underlying organ failure in disease and aging …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …

How are biological structures maintained in a cellular environment that constantly threatens
protein integrity? Here we elucidate proteostasis mechanisms affecting the Z disk, a protein …

Histone deacetylases (HDACs) regulate cardiac plasticity; however, their molecular targets
are unknown. As autophagy contributes to pathological cardiac remodeling, we …

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Cells maintain a healthy proteome through continuous evaluation of the quality of each of
their proteins. Quality control requires the coordinated action of chaperones and proteolytic …

The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral
to the development of the cardiovascular system and cardiovascular diseases. The UPS …