Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Despite substantial advances in the diagnosis of cardiovascular disease, 18 F-labeled
positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose …

Radiolabeled lipophilic cationic compounds, such as 18F-labeled phosphonium salt,
accumulate in the mitochondria through a negative inner transmembrane potential. The …

Lipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the
plasma and mitochondrial membranes and accumulate in mitochondria in response to the …

INTRODUCTION: Established radiotracers for positron emission tomography (PET)
myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit …

[18F]-labeled molecular probe for the detection of myocardial perfusion deficit is driving
particular interest due to its high clinical applicability. Thus, we synthesized (2-(2-[18F] …

Despite substantial advances in the diagnosis of cardiovascular disease, there is a need for
18F-labeled myocardial perfusion agents for the diagnosis of ischemic heart disease …

Coronary artery disease (CAD) is the leading cause of death in the world. Myocardial
perfusion imaging (MPI) plays a significant role in non-invasive diagnosis and prognosis of …

Abstract Introduction 99m Tc-Teboroxime ([99m TcCl (CDO)(CDOH) 2 BMe]) is a member of
the BATO (boronic acid adducts of technetium dioximes) class of 99m Tc (III) complexes …

We have previously reported that radiolabeled phosphonium cations accumulate in the
mitochondria down a transmembrane potential gradient. We present an optimized …