Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

SMC Gobeil, K Janowska, S McDowell, K Mansouri… - Science, 2021 - science.org
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

DR Martinez, A Schäfer, SR Leist, G De la Cruz, A West… - Science, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 and
SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against …

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

MG Joyce, WH Chen, RS Sankhala, A Hajduczki… - Cell reports, 2021 - cell.com
The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-
generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the …

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

HAD King, MG Joyce, I Lakhal-Naouar… - Proceedings of the …, 2021 - National Acad Sciences
Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable …

[HTML][HTML] A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

DR Martinez, A Schaefer, S Gobeil, D Li, G De la Cruz… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Abstract SARS-CoV in 2003, SARS-CoV-2 in 2019, and SARS-CoV-2 variants of concern
(VOC) can cause deadly infections, underlining the importance of developing broadly …

Efficacy of a broadly neutralizing SARS-CoV-2 ferritin nanoparticle vaccine in nonhuman primates

MG Joyce, HAD King, IE Naouar, A Ahmed… - BioRxiv, 2021 - biorxiv.org
The emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants stresses the continued need for next-generation vaccines that confer broad …

Immunogenicity and neutralizing activity comparison of SARS-CoV-2 spike full-length and subunit domain proteins in young adult and old-aged mice

KH Kim, N Bhatnagar, S Jeeva, J Oh, BR Park, CH Shin… - Vaccines, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be expanding
the pandemic disease across the globe. Although SARS-CoV-2 vaccines were rapidly …

[HTML][HTML] Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model

KV Kalnin, T Plitnik, M Kishko, D Huang, A Raillard… - Vaccine, 2022 - Elsevier
The emergence of SARS-CoV-2 variants, especially Beta and Delta, has raised concerns
about the reduced protection from previous infection or vaccination based on the original …

[HTML][HTML] Antigen Delivery Systems: Past, Present, and Future

HJ Ko, YJ Kim - Biomolecules & Therapeutics, 2023 - ncbi.nlm.nih.gov
The COVID-19 pandemic has increased demand for safe and effective vaccines. Research
to develop vaccines against diseases including Middle East respiratory syndrome …

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

F Borriello, E Nanishi, HS Seo, TR O'Meara… - BioRxiv, 2021 - biorxiv.org
Development of affordable and effective vaccines that can also protect vulnerable
populations such as the elderly from COVID-19-related morbidity and mortality is a public …