Drug-induced liver injury is an important cause of hepatotoxicity and poses a challenging
clinical problem with respect to both diagnosis and management. Patients susceptible to …

In the first part of the review, topical agents and first-line systemic treatment options for
cutaneous lupus erythematosus were discussed whereas in the second part, recent …

A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

In celiac disease, the ingestion of gluten-containing cereals, such as wheat, rye, and barley,
results in small-bowel mucosal inflammation and villous atrophy with crypt hyperplasia. The …

Background: In major depressive disorder (MDD), findings include hyperstable regulation of
brain arousal measured by electroencephalography (EEG) vigilance analysis and …

The incidence of drug‐induced neutropenia has not changed in the western hemisphere
over the last 30 years. Yet, the drug panorama has changed considerably. This implies that …

Dermatitis herpetiformis (DH), a particularly pruritic bullous skin disease that predominantly
affects the extensor surfaces of elbows, knees, buttocks, back, and scalp, is one part of a …

Dapsone-induced hypersensitivity reactions may cause severe cutaneous adverse
reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS). It has …

Abstract Dapsone (4, 4'-diaminodiphenylsulfone, DDS) was synthesized a century ago and
continues to be a powerful therapeutic tool in many skin diseases. We have tried to retrieve …