Glycan microarrays from construction to applications

Y Kim, JY Hyun, I Shin - Chemical Society Reviews, 2022 - pubs.rsc.org
Through their specific interactions with proteins, cellular glycans play key roles in a wide
range of physiological and pathological processes. One of the main goals of research in the …

Recent progress of glycopolymer synthesis for biomedical applications

I Pramudya, H Chung - Biomaterials science, 2019 - pubs.rsc.org
Glycopolymers are an important class of biomaterials which include carbohydrate moieties
in their polymer structure. In addition to biological research on the interactions of …

Synthetic glycoscapes: addressing the structural and functional complexity of the glycocalyx

SC Purcell, K Godula - Journal of the Royal Society …, 2019 - royalsocietypublishing.org
The glycocalyx is an information-dense network of biomacromolecules extensively modified
through glycosylation that populates the cellular boundary. The glycocalyx regulates …

High throughput preparation of UV-protective polymers from essential oil extracts via the Biginelli reaction

T Mao, G Liu, H Wu, Y Wei, Y Gou… - Journal of the …, 2018 - ACS Publications
A high throughput (HTP) system has been developed to exploit new functional polymers. We
synthesized 25 monomers in a mini-HTP manner through the tricomponent Biginelli reaction …

High throughput screening of glycopolymers: balance between cytotoxicity and antibacterial property

Y Zheng, Y Luo, K Feng, W Zhang, G Chen - ACS Macro Letters, 2019 - ACS Publications
To search for synthetic agents with low cytotoxicity and good antibacterial activity is essential
for antimicrobial applications. Here we report a high throughput technique that carried out in …

Sequence-controlled glycooligomers for tumor targeting

J Chen, Y Zhang, Q Gao, W Wang, L Zhu… - Cell Reports Physical …, 2024 - cell.com
Cancers of diverse origins exhibit more rapid and greater carbohydrate uptake and
consumption compared to normal cells, making carbohydrate an efficient cancer-targeting …

Mannoside-modified branched gold nanoparticles for photothermal therapy to MDA-MB-231 cells

HC Lin, KF Hsu, CL Lai, TC Wu, HF Chen, CH Lai - Molecules, 2020 - mdpi.com
Recently, gold nanoparticles (Au NPs) have been used to study the treatment of malignant
tumors due to their higher biocompatibility and lesser toxicity. In addition, they can be …

High-throughput preparation of antibacterial polymers from natural product derivatives via the Hantzsch reaction

G Liu, Q Zhang, Y Li, X Wang, H Wu, Y Wei, Y Zeng… - IScience, 2020 - cell.com
The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-
throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six …

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

MR Tavares, M Pechar, P Chytil… - Macromolecular …, 2021 - Wiley Online Library
This paper summarizes the area of biomedicinal polymers, which serve as nanomedicines
even though they do not contain any anticancer or antiinflammatory drugs. These polymer …

Glycopolymer Microarrays with Sub‐Femtomolar Avidity for Glycan Binding Proteins Prepared by Grafted‐To/Grafted‐From Photopolymerizations

DJ Valles, YS Zholdassov, J Korpanty… - Angewandte …, 2021 - Wiley Online Library
We report a novel glycan array architecture that binds the mannose‐specific glycan binding
protein, concanavalin A (ConA), with sub‐femtomolar avidity. A new radical …