ESCRT-III is required for lipid membrane remodeling in many cellular processes, from
abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III …

A cell membrane can be considered a liquid-phase plane in which lipids and proteins
theoretically are free to diffuse. Numerous reports, however, describe retarded diffusion of …

During asymmetric division, fate determinants at the cell cortex segregate unequally into the
two daughter cells. It has recently been shown that Sara (Smad anchor for receptor …

Single-molecule techniques are being increasingly applied to biomedical investigation,
notwithstanding the numerous challenges they pose in terms of signal-to-noise ratio issues …

Single molecule tracking of membrane proteins by fluorescence microscopy is a promising
method to investigate dynamic processes in live cells. Translating the trajectories of proteins …

During asymmetric division, fate assignation in daughter cells is mediated by the partition of
determinants from the mother. In the fly sensory organ precursor cell, Notch signalling …

Decades of traditional biochemistry, structural approaches, and, more recently, single-
molecule-based in vitro techniques have provided us with an astonishingly detailed …

: Tracking of single fluorescent probes along the axial (depth) dimension is an important task
in the biological and physical sciences. In this paper, we propose and analyze the use of …

Precise localisation of intracellular organelles impacts a myriad of cellular processes
including cell motility, polarisation and mitosis. Positioning is actively controlled by organelle …

Sorting of cargoes in endosomes occurs through their concentration into sorting platforms,
called microdomains, from which transport intermediates are formed. The WASH complex …