Radiosynthesis and in silico bioevaluation of 131I‐Sulfasalazine as a highly selective radiotracer for imaging of ulcerative colitis

MH Sanad, SFA Rizvi, AB Farag - Chemical Biology & Drug …, 2021 - Wiley Online Library
This study demonstrated the tracking of ulcerative colitis, which is considered a stressful
immune disease. Although there are many ways to test for this disease including …

Radioiodination of balsalazide, bioevaluation, and characterization as a highly selective radiotracer for imaging of ulcerative colitis in mice

MH Sanad, NM Gomaa, NM El Bakary… - Journal of Labelled …, 2022 - Wiley Online Library
This work focuses on tracking ulcerative colitis in mice. High labeling yield and
radiochemical purity were achieved for the formation of a [125/131I] balsalazide radiotracer …

Molecular imaging in preclinical models of IBD with nuclear imaging techniques: state-of-the-art and perspectives

E Kaaru, A Bianchi, A Wunder… - Inflammatory bowel …, 2016 - academic.oup.com
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is
characterized by chronic unregulated inflammation of the intestinal mucosa of the …

99mTc-Mesalamine as potential agent for diagnosis and monitoring of ulcerative colitis: labelling, characterisation and biological evaluation

OA El-Kawy, MH Sanad, F Marzook - Journal of Radioanalytical and …, 2016 - Springer
Mesalamine was labelled with technetium-99m (99m Tc) in high radiolabelling yield (~
98.4%), in vitro stability (~ 4 h) and in serum persistence (~ 24 h). Optimum labelling …

Synthesis, Radiolabeling, and Biological Evaluation of 99mTc-Tricarbonyl Mesalamine as a Potential Ulcerative Colitis Imaging Agent

MH Sanad, HM Eyssa, FA Marzook, SFA Rizvi… - Radiochemistry, 2021 - Springer
A complex of 99mTc tricarbonyl with Mesalamine for ulcerative colitis imaging was prepared
and studied. Several factors such as substrate concentration, pH, reaction period, and …

Radioiodination and biological evaluation of mesalamine as a tracer for ulcerative colitis imaging

MH Sanad, HM Talaat, ASM Fouzy - Radiochimica Acta, 2018 - degruyter.com
This study aims to evaluate newly radioiodinated mesalamine (Mes) as a tracer for
ulcerative colitis imaging. Mes was labeled with [125I] with chloramine-T (Ch-T) as the …

In-Silico Study, Preparation and Biological Evaluation of 99MTC-Mesalamine Complex as Radiotracer for Diagnostics and Monitoring of Ulcerative Colitis in Mice

MH Sanad, SFA Rizvi, FA Marzook… - Pharmaceutical Chemistry …, 2022 - Springer
This work centralizes on pursuit ulcerative colitis localized in mice. High radiolabeling and
purity were ensured during the formation of a radiotracer,[99mTc] nitrido-mesalamine …

Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection

BM Essa, AA Selim, OA El-Kawy… - International journal of …, 2022 - Taylor & Francis
Background Nanomedicine offers great potential for scintigraphic diagnostic imaging with
lower risk and higher quality compared to other traditional techniques. Objectives This work …

99mTc-roxifiban: a potential molecular imaging agent for the detection and localization of acute venous thrombosis

OA El-Kawy, JA García-Horsman - Journal of Radioanalytical and Nuclear …, 2017 - Springer
Abstract 99m Tc-roxifiban was obtained in a high radiochemical yield (98.4%) by
complexing~ 750 MBq 99m Tc with 2.5 mg roxifiban in the presence of 150 µg SnCl 2· 2H 2 …

99mTc-labeled glimepiride as a tracer for targeting pancreatic β-cells mass: preparation and preclinical evaluation

OA El-Kawy, JA García-Horsman - Journal of Radioanalytical and Nuclear …, 2017 - Springer
Complexation of glimepiride with 99m Tc, factors affecting yield and suitability of the 99m Tc-
glimepiride as a tracer for pancreatic β-cells mass were investigated. The radiocomplex …