As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Statins are widely prescribed cholesterol-lowering drugs that inhibit HMG-CoA reductase
(HMGCR), the rate-limiting enzyme of the mevalonate metabolic pathway. Multiple lines of …

Simple Summary Metabolic reprogramming is gaining attentions as a hallmark of cancers.
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …

Missense mutations in the TP53 gene lead to accumulation of dysfunctional TP53 proteins in
tumors, showing oncogenic gain-of-function (GOF) activities. Stabilization of mutant TP53 …

Enhanced proliferation and survival are common features of cancer cells. Cancer cells are
metabolically reprogrammed which aids in their survival in nutrient-poor environments …