The MS2 and MS2-coat protein (MS2-MCP) imaging system is widely used to study
messenger RNA (mRNA) spatial distribution in living cells. Here, we report that the MS2 …

The translation of messenger RNA (mRNA) into proteins represents the culmination of gene
expression. Recent technological advances have revolutionized our ability to investigate this …

Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling
network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is …

The double-stranded RNA sensor kinase PKR is one of four integrated stress response
(ISR) sensor kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α) …

The endoplasmic reticulum (ER) regulates essential cellular processes, including protein
folding, lipid synthesis, and calcium homeostasis. The ER homeostasis is maintained by a …

Abstract Changes in lipid metabolism are associated with aging and age-related diseases,
including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein …

Conserved signaling cascades monitor protein-folding homeostasis to ensure proper
cellular function. One of the evolutionary conserved key players is IRE1, which maintains …

Upon accumulation of unfolded proteins at the endoplasmic reticulum (ER), IRE1 activates
the unfolded protein response (UPR) to restore protein-folding homeostasis. During ER …

The endoplasmic reticulum (ER), a cellular organelle that forms a cell-spanning network of
tubes and sheets, is an important location of protein synthesis and folding. When the ER …

The Unfolded Protein Response (UPR) is composed by homeostatic signaling pathways that
are activated by the accumulation of misfolded proteins in the Endoplasmic Reticulum (ER) …