Supramolecular assemblies in bacterial immunity: an emerging paradigm

L Payne, S Jackson, R Pinilla-Redondo - Trends in Microbiology, 2024 - cell.com
The study of bacterial immune systems has recently gained momentum, revealing a
fascinating trend: many systems form large supramolecular assemblies. Here, we examine …

[HTML][HTML] Principles of bacterial innate immunity against viruses

MT Laub, A Typas - Current Opinion in Immunology, 2024 - Elsevier
All organisms must defend themselves against viral predators. This includes bacteria, which
harbor immunity factors such as restriction-modification systems and CRISPR-Cas systems …

Expanding the Phage Galaxy: Isolation and Characterization of Five Novel Streptomyces Siphoviruses Ankus, Byblos, DekoNeimoidia, Mandalore, and Naboo

SH Erdrich, T Luthe, L Kever, B Badia Roigé, B Arsova… - PHAGE, 2024 - liebertpub.com
Background: Key features of the actinobacterial genus Streptomyces are multicellular,
filamentous growth, and production of a broad portfolio of bioactive molecules. These …

Isolation and characterization of the new Streptomyces phages Kamino, Geonosis, Abafar, and Scarif infecting a broad range of host species

B Rackow, C Rolland, I Mohnen, J Wittmann… - Microbiology …, 2024 - journals.asm.org
Streptomyces, a multifaceted genus of soil-dwelling bacteria belonging to the phylum
Actinomycetota, features intricate phage-host interactions shaped by its complex life cycle …

[HTML][HTML] A novel genus of Pectobacterium bacteriophages display broad host range by targeting several species of Danish soft rot isolates

JS Pedersen, AB Carstens, MM Rothgard, C Roy… - Virus Research, 2024 - Elsevier
The bacterial diseases black leg and soft rot in potatoes cause heavy losses of potatoes
worldwide. Bacteria within the genus Pectobacteriaceae are the causative agents of black …

[HTML][HTML] Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr

T Kurata, M Takegawa, T Ohira, EA Syroegin… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Translation-targeting toxic Small Alarmone Synthetases (toxSAS) are effectors of
bacterial Toxin-Antitoxin systems that pyrophosphorylate the 3'-CCA end of tRNA to prevent …

Molecular basis of foreign DNA recognition by BREX anti-phage immunity system

A Drobiazko, M Adams, M Skutel, K Potekhina… - bioRxiv, 2024 - biorxiv.org
Anti-phage systems of the BREX (BacteRiophage EXclusion) superfamily rely on epigenetic
DNA methylation to discriminate between the host and invading DNA, but their mechanism …

A versatile bacterial innate immunity protein directly senses two disparate phage proteins

T Zhang, A Cepauskas, A Nadieina, A Thureau… - bioRxiv, 2024 - biorxiv.org
Eukaryotic innate immune systems use pattern recognition receptors (PRRs) to sense
infection by detecting pathogen-associated molecular patterns, which then triggers an …

The growing repertoire of phage anti-defence systems

K Murtazalieva, A Mu, A Petrovskaya, RD Finn - Trends in Microbiology, 2024 - cell.com
The biological interplay between phages and bacteria has driven the evolution of phage anti-
defence systems (ADSs), which evade bacterial defence mechanisms. These ADSs bind …