Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Automated microscopy has given researchers access to great amounts of live cell imaging
data from in vitro and in vivo experiments. Much focus has been put on extracting cell tracks …

After traumatic injury, some cells function as detectors to sense injury and to modulate the
local immune response toward a restitution phase by affecting the local cytokine milieu …

Natural killer (NK) cells lyse invading tumor cells to limit metastatic growth in the lung, but
how some cancers evade this host protective mechanism to establish a growing lesion is …

Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of
tumors. Most mechanistic studies focus on their static functional status before or after …

Coinhibitory molecules, such as PD-1, CTLA-4, 2B4, and BTLA, are an important new family
of mediators in the pathophysiology of severe bacterial and/or fungal infection, as well as the …

Pigs are important livestock and comprehensive understanding of their immune responses
in infections is critical to improve vaccines and therapies. Moreover, similarities between …

Background: Sepsis is marked by a dysregulated immune response to an infection. Invariant
natural killer T cells (iNKT cells) are a pluripotent lymphocyte subpopulation capable of …

Invariant NKT (iNKT) cells express markers of both T and NK cells and may produce various
cytokines to regulate liver immunity. However, the role of iNKT cells in the progression of …

Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes
(symptoms, age at onset, atopy, and lung function) may result from different pathogenic …