Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency
RA Montel, C Munoz-Zuluaga, KM Stiles… - Cancer gene …, 2022 - nature.com
Approximately 8% of the world population and 35–45% of East Asians are carriers of the
hereditary disorder aldehyde dehydrogenase 2 (ALDH2) deficiency. ALDH2 plays a central …
hereditary disorder aldehyde dehydrogenase 2 (ALDH2) deficiency. ALDH2 plays a central …
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA
J Key, S Torres-Odio, NC Bach, S Gispert, G Koepf… - Cells, 2021 - mdpi.com
Biallelic pathogenic variants in CLPP, encoding mitochondrial matrix peptidase ClpP, cause
a rare autosomal recessive condition, Perrault syndrome type 3 (PRLTS3). It is characterized …
a rare autosomal recessive condition, Perrault syndrome type 3 (PRLTS3). It is characterized …
Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein
S Matsumoto, H Taniguchi-Tamura, M Araki… - Biochemical and …, 2021 - Elsevier
GTP-bound forms of Ras proteins (Ras• GTP) assume two interconverting conformations,“
inactive” state 1 and “active” state 2. Our previous study on the crystal structure of the state 1 …
inactive” state 1 and “active” state 2. Our previous study on the crystal structure of the state 1 …
[HTML][HTML] Discovery of novel small-molecule aldehyde dehydrogenase 2 activators based on drug repurposing
W Tian, X Sun, X Gao, W Wang, Z Chen, X Chen… - Journal of Saudi …, 2023 - Elsevier
Abstract Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the detoxification of
reactive aldehydes under oxidative stress. Because an estimated 50% of East Asians carry a …
reactive aldehydes under oxidative stress. Because an estimated 50% of East Asians carry a …