The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Abstract Mitochondrial calcium (mCa2+) has a central role in both metabolic regulation and
cell death signalling, however its role in homeostatic function and disease is controversial …

Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation–
contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP …

In recent years, rapid discoveries have been made relating to Ca 2+ handling at specific
organelles that have important implications for whole-cell Ca 2+ homeostasis. In particular …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …