Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Q Long, P Zheng, X Zheng, W Li, L Hua, Z Yang… - Advanced drug delivery …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

Trained immunity: Target for prophylaxis and therapy

A Ziogas, M Bruno, R van der Meel, WJM Mulder… - Cell Host & Microbe, 2023 - cell.com
Trained immunity is a de facto memory for innate immune responses, leading to long-term
functional reprogramming of innate immune cells. In physiological conditions, trained …

Trained immunity-related vaccines: innate immune memory and heterologous protection against infections

A Ziogas, MG Netea - Trends in molecular medicine, 2022 - cell.com
The innate immune system is able to build memory-like features in response to certain
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …

Early-life respiratory infections and developmental immunity determine lifelong lung health

CM Lloyd, S Saglani - Nature Immunology, 2023 - nature.com
Respiratory infections are common in infants and young children. However, the immune
system develops and matures as the child grows, thus the effects of infection during this time …

[HTML][HTML] Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells

Y Yamaguchi, Y Kato, R Edahiro, JN Søndergaard… - Jci Insight, 2022 - ncbi.nlm.nih.gov
Consecutive mRNA vaccinations against SARS-CoV-2 reinforced both innate and adaptive
immune responses. However, it remains unclear whether the enhanced innate immune …

Innate immune memory in inflammatory arthritis

MM Jeljeli, IE Adamopoulos - Nature Reviews Rheumatology, 2023 - nature.com
The concept of immunological memory was demonstrated in antiquity when protection
against re-exposure to pathogens was observed during the plague of Athens …

Trained immunity inducers in cancer immunotherapy

Y Sui, JA Berzofsky - Frontiers in immunology, 2024 - frontiersin.org
While most of the cancer immunotherapy strategies engage adaptive immunity, especially
tumor-associated T cells, the small fraction of responding patients and types of cancers …

Innate (learned) memory

B Al, TK Suen, K Placek, MG Netea - Journal of Allergy and Clinical …, 2023 - Elsevier
With the growing body of evidence, it is now clear that not only adaptive immune cells but
also innate immune cells can mount a more rapid and potent non-specific immune response …

From Amish farm dust to bacterial lysates: the long and winding road to protection from allergic disease

D Vercelli - Seminars in Immunology, 2023 - Elsevier
Allergic diseases typically begin in early life and can impose a heavy burden on children
and their families. Effective preventive measures are currently unavailable but may be …