Thermoacidophilic archaea belonging to the order Sulfolobales thrive in extreme biotopes,
such as sulfuric hot springs and ore deposits. These microorganisms have been model …

Reversible protein phosphorylation is the main mechanism of signal transduction that
enables cells to rapidly respond to environmental changes by controlling the functional …

Gravitational wave astronomy has established its role in measuring the equation of state
governing cold supranuclear matter. To date and in the near future, gravitational wave …

INTRODUCTION Eukaryotes likely arose from a symbiotic partnership between an archaeal
host and an alpha-proteobacterium, giving rise to the cell body and the mitochondria …

The reversible attachment of ubiquitin (Ub) and ubiquitin like modifiers (Ubls) to proteins are
crucial post-translational modifications (PTMs) for many cellular processes. Not only do cells …

In natural environments microorganisms encounter extreme changes in temperature, pH,
osmolarities and nutrient availability. The stress response of many bacterial species has …

The molecular mechanisms of targeted proteolysis in archaea are poorly understood, yet
they may have deep evolutionary roots shared with the ubiquitin-proteasome system of …

High-temperature stress is critical for all organisms and induces a profound cellular
response. For Crenarchaeota, little information is available on how heat shock affects …

The yeast peroxiredoxin Ahp1, like related anti-oxidant enzymes in other species,
undergoes urmylation, a lysine-directed conjugation to ubiquitin-like modifier Urm1. Ahp1 …

The covalent modification of protein substrates by ubiquitin regulates a diverse range of
critical biological functions. Although it has been established that ubiquitin-like modifiers …