Genetic and diet-induced animal models for non-alcoholic fatty liver disease (NAFLD) research

CM Flessa, N Nasiri-Ansari, I Kyrou, BM Leca… - International Journal of …, 2022 - mdpi.com
A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

N Bolshette, H Ibrahim, H Reinke… - Nature Reviews …, 2023 - nature.com
A wide variety of liver functions are regulated daily by the liver circadian clock and via
systemic circadian control by other organs and cells within the gastrointestinal tract as well …

[HTML][HTML] Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

JG Smith, KB Koronowski, T Mortimer, T Sato… - Cell reports, 2023 - cell.com
Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the
rhythms generated by the concerted activity of these clocks is associated with metabolic …

[HTML][HTML] Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca2+ overload

N Zhang, H Yu, T Liu, Z Zhou, B Feng, Y Wang, Z Qian… - Redox Biology, 2023 - Elsevier
Brain and muscle arnt-like protein 1 (Bmal1) is a crucial transcription factor, regulating
circadian rhythm and involved in multiple heart diseases. However, it is unknown whether …

Circadian clock regulation via biomaterials for nucleus pulposus

W Chen, D Zheng, H Chen, T Ye, Z Liu, J Qi… - Advanced …, 2023 - Wiley Online Library
Circadian clock disorder during tissue degeneration has been considered the potential
pathogenesis for various chronic diseases, such as intervertebral disc degeneration (IVDD) …

Sonic hedgehog-heat shock protein 90β axis promotes the development of nonalcoholic steatohepatitis in mice

W Zhang, J Lu, L Feng, H Xue, S Shen, S Lai… - Nature …, 2024 - nature.com
Sonic hedgehog (SHH) and heat shock protein 90β (HSP90β) have been implicated in
nonalcoholic steatohepatitis (NASH) but their molecular mechanisms of action remain …

The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease—the transition from an adipocentric to liver …

M Vesković, N Šutulović, D Hrnčić… - Current issues in …, 2023 - mdpi.com
The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …

The role of the circadian clock in the development, progression, and treatment of non‐alcoholic fatty liver disease

LVM de Assis, M Demir, H Oster - Acta Physiologica, 2023 - Wiley Online Library
The circadian clock comprises a cellular endogenous timing system coordinating the
alignment of physiological processes with geophysical time. Disruption of circadian rhythms …

[HTML][HTML] Characterisation of hepatic lipid signature distributed across the liver zonation using mass spectrometry imaging

P Seubnooch, M Montani, S Tsouka, E Claude… - JHEP reports, 2023 - Elsevier
Abstract Background & Aims Lipid metabolism plays an important role in liver
pathophysiology. The liver lobule asymmetrically distributes oxygen and nutrition, resulting …

Circadian regulation of liver metabolism: Experimental approaches in human, rodent, and cellular models

LJ Daniels, D Kay, T Marjot… - American Journal of …, 2023 - journals.physiology.org
Circadian rhythms are endogenous oscillations with approximately a 24-h period that allow
organisms to anticipate the change between day and night. Disruptions that desynchronize …