α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic'neurotoxins, they …
CD Dellisanti, Y Yao, JC Stroud, ZZ Wang… - Nature neuroscience, 2007 - nature.com
We determined the crystal structure of the extracellular domain of the mouse nicotinic acetylcholine receptor (nAChR) α1 subunit bound to α-bungarotoxin at 1.94 Å resolution …
The crystal structure of the snake long α‐neurotoxin, α‐cobratoxin, bound to the pentameric acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …
S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …
Mutations in eat-2 and eat-18 cause the same defect in C. elegans feeding behavior: the pharynx is unable to pump rapidly in the presence of food. EAT-2 is a nicotinic acetylcholine …
VI Tsetlin, F Hucho - FEBS letters, 2004 - Elsevier
This review covers recent data on interactions of nicotinic acetylcholine receptors (AChR) with snake venom proteins (α-and κ-neurotoxins,'weak'toxins recently shown to act on …
Z Biron, S Khare, AO Samson, Y Hayek, F Naider… - Biochemistry, 2002 - ACS Publications
The peptide gp41659-671 (ELLELDKWASLWN) comprises the entire epitope for one of the three known antibodies capable of neutralizing a broad spectrum of primary HIV-1 isolates …
A Gołaszewska, W Bik, T Motyl… - International journal of …, 2019 - mdpi.com
The average life span steadily grows in humans and in animals kept as pets or left in sanctuaries making the issue of elderly-associated cognitive impairment a hot-spot for …
The three-fingered toxin family and more precisely short-chain α-neurotoxins (also known as Type I α-neurotoxins) are crucial in defining the elapid envenomation process, but …