ER remodeling via ER-phagy

A Gubas, I Dikic - Molecular Cell, 2022 - cell.com
The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER
membrane is highly dynamic, which affects many cellular processes that take place within …

Type I interferons and endoplasmic reticulum stress in health and disease

J Sprooten, AD Garg - International review of cell and molecular biology, 2020 - Elsevier
Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed,
by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing …

Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain …

Y Liu, Y Gong, W Xie, A Huang, X Yuan, H Zhou, X Zhu… - Nanoscale, 2020 - pubs.rsc.org
The delivery of drugs across the blood–brain barrier (BBB) effectively and safely is one of
the major challenges in the treatment of neurodegenerative diseases. In this work, we …

Hallmarks of neurodegenerative disease: A systems pharmacology perspective

P Bloomingdale, T Karelina… - CPT …, 2022 - Wiley Online Library
Age‐related central neurodegenerative diseases, such as Alzheimer's and Parkinson's
disease, are a rising public health concern and have been plagued by repeated drug …

Common factors in neurodegeneration: a meta-study revealing shared patterns on a multi-omics scale

N Ruffini, S Klingenberg, S Schweiger, S Gerber - Cells, 2020 - mdpi.com
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous …

All roads lead to Rome: different molecular players converge to common toxic pathways in neurodegeneration

S Argueti-Ostrovsky, L Alfahel, J Kahn, A Israelson - Cells, 2021 - mdpi.com
Multiple neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's
disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are being …

Genistein attenuates memory impairment in Alzheimer's disease via ERS-mediated apoptotic pathway in vivo and in vitro

H Gao, X Lei, S Ye, T Ye, R Hua, G Wang… - The Journal of …, 2022 - Elsevier
Genistein (GS), an isoflavone compound found in soybean, plays a neuroprotective role in
Alzheimer's disease (AD). However, the mechanism of its action remains unclear. Herein …

Mitochondrial dysfunction and endoplasmic reticulum stress in age related macular degeneration, role in pathophysiology, and possible new therapeutic strategies

V Bilbao-Malavé, J González-Zamora, M de la Puente… - Antioxidants, 2021 - mdpi.com
Age related macular degeneration (AMD) is the main cause of legal blindness in developed
countries. It is a multifactorial disease in which a combination of genetic and environmental …

Deltamethrin-evoked ER stress promotes neuroinflammation in the adult mouse hippocampus

MM Hossain, AC Toltin, LM Gamba, MA Molina - Cells, 2022 - mdpi.com
Endoplasmic reticulum (ER) stress and neuroinflammation are involved in the pathogenesis
of many neurodegenerative disorders. Previously, we reported that exposure to pyrethroid …

The role of PERK-eIF2α-ATF4-CHOP pathway in sevoflurane induced neuroapoptosis and cognitive dysfunction in aged mice

Y Wang, D Wu, D Li, X Zhou, D Fan, J Pan - Cellular Signalling, 2023 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common surgical complication that causes
additional pain in patients and affects their quality of life. To address this problem, emerging …