Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Tubulointerstitial fibrosis, tubular atrophy, and peritubular capillary rarefaction are major
hallmarks of chronic kidney disease. The tubulointerstitium consists of multiple cell …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Rationale: Renal fibrosis is the terminal manifestation of chronic and irreversible renal
disease. Effective therapies other than dialysis are extremely limited. In this study, we …

Recent evidences indicate that signal transducer and activator of transcription 3 (STAT3) is
one of the crucial signaling pathways in the progression of diabetic nephropathy (DN). Here …

Indoxyl sulfate (IS), a uremic toxin, causes chronic kidney disease (CKD) progression via its
tubulotoxicity. After cellular uptake, IS directly induces apoptotic and necrotic cell death of …

Abstract Ethnopharmacological relevance Traditional Chinese medicine provides a unique
curative treatment of complex chronic diseases, including chronic kidney disease (CKD) …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway is a multifaceted transduction system that regulates cellular responses to incoming …

Current understanding of fibrosis remains incomplete despite the increasing burden of
related diseases. Preclinical models are used to dissect the pathogenesis and dynamics of …

Signal transducer and activator of transcription 3 (STAT3) is a cell-signal transcription factor
that has attracted considerable attention in recent years. The stimulation of cytokines and …