Investigation of mesalazine-cobalt (III) complexes for hypoxia-activated prodrug development

SS Santana, M Lanznaster - Inorganic Chemistry Communications, 2023 - Elsevier
Cobalt (III) complexes have been designed to coordinate and selectively deliver bioactive
molecules to hypoxic regions of solid tumors. In this way, we report the synthesis …

Impact of pore–walls ligand assembly on the biodegradation of mesoporous Organosilica nanoparticles for controlled drug delivery

H Omar, B Moosa, K Alamoudi, DH Anjum… - Acs Omega, 2018 - ACS Publications
Porous materials with molecular-scale ordering have attracted major attention mainly
because of the possibility to engineer their pores for selective applications. Periodic …

Investigation of pH-sensitive galactopyranoside glycol hydrogels as effective vehicles for oral drug delivery

S Zakhireh, M Mahkam, M Yadollahi… - Journal of Polymer …, 2014 - Springer
High-loading-capacity pH-sensitive glycol hydrogels were developed using allyl α-D-
galactopyranoside as a biodegradable and biocompatible carbohydrate. These new pH …

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

GV Martinez, S Navath, K Sewda, V Rao… - Bioorganic & medicinal …, 2013 - Elsevier
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of
an azide-terminated Gd–DOTA complex were attached via copper (I)-catalyzed azide-alkyne …

Palladium-catalyzed hydrogenations in dichloromethane

DJ Mason, YG Timofeyenko, B Jagadish… - Synthetic …, 2022 - Taylor & Francis
Dichloromethane is shown to be a useful solvent in catalytic hydrogenation reactions of
easily reduced functional groups (alkenes, alkynes, imines, and nitroarenes) using …

Exploiting enzyme alterations in cancer for drug activation, drug delivery, and nanotherapy

JY Hayashi, F Tamanoi - The Enzymes, 2017 - Elsevier
Alterations of enzyme activity or enzyme levels in cancer tissue have been documented over
the years. Taking advantage of these observations, various strategies for drug activation and …

Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted …

VM Radhakrishnan, P Kojs, R Ramalingam… - Journal of Biological …, 2015 - ASBMB
NCX1 is a Na+/Ca 2+ exchanger, which is believed to provide a key route for basolateral Ca
2+ efflux in the renal epithelia, thus contributing to renal Ca 2+ reabsorption. Altered mineral …

Novel Materials Comprised of Molecular Springs: Synthetic Approaches to Bridgehead-Substituted Bicyclo [nnn] Alkane Monomers

DJ Mason - 2023 - search.proquest.com
Materials and polymer chemistry are a huge part of our everyday world. From replacing
hazardous glass materials with shatterproof plastic to wet and leaky diapers being upgraded …

Investigation of Mesalazine-Cobalt (Iii) Complexes for Hypoxia-Activated Prodrug Development

M Lanznaster, SS Santana - Available at SSRN 4399380 - papers.ssrn.com
Synthesis, electrochemistry and spectroscopic properties and reactivity of three mesalazine-
cobalt (III) complexes are reported. An effects of donor/acceptor capabilities of the ancillary …