Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis
Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent
infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for …
infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for …
Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy
A Lalvani - Chest, 2007 - Elsevier
The century-old tuberculin skin test (TST) was until recently the only means of diagnosing
latent tuberculosis infection (LTBI). Recent advances in mycobacterial genomics and human …
latent tuberculosis infection (LTBI). Recent advances in mycobacterial genomics and human …
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major
cellular component of TB lung granulomas and are known to play an important role in …
cellular component of TB lung granulomas and are known to play an important role in …
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease
TJ Scriba, A Penn-Nicholson, S Shankar… - PLoS …, 2017 - journals.plos.org
Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …
infection to pulmonary tuberculosis disease in humans remains limited. To define such …
Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis
V Guyot-Revol, JA Innes, S Hackforth… - American journal of …, 2006 - atsjournals.org
Rationale: T-cell responses during tuberculosis (TB) help contain Mycobacterium
tuberculosis in vivo but also cause collateral damage to host tissues. Immune regulatory …
tuberculosis in vivo but also cause collateral damage to host tissues. Immune regulatory …
Human immunology of tuberculosis
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …
Advances in the diagnosis of tuberculosis
C Lange, T Mori - Respirology, 2010 - Wiley Online Library
Tuberculosis ranges among the leading causes of morbidity and mortality worldwide. A
diagnostic approach to a patient with possible tuberculosis includes a detailed medical …
diagnostic approach to a patient with possible tuberculosis includes a detailed medical …
A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans
CS Lindestam Arlehamn, DM McKinney… - PLoS …, 2016 - journals.plos.org
We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity
of human pathogen specific responses in healthy individuals infected with M. tuberculosis …
of human pathogen specific responses in healthy individuals infected with M. tuberculosis …
T-cell interferon-γ release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings
K Dheda, R van Zyl Smit, M Badri… - Current opinion in …, 2009 - journals.lww.com
IGRAs may still be useful in high-burden settings in specific subgroups at high risk of
progression, including young children, HIV-infected individuals and healthcare workers, but …
progression, including young children, HIV-infected individuals and healthcare workers, but …