Structure and function of chromatin remodelers
AA Reyes, RD Marcum, Y He - Journal of molecular biology, 2021 - Elsevier
Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …
remodelers and histone modifying enzymes are integral to the process of gene regulation …
Modular organization and assembly of SWI/SNF family chromatin remodeling complexes
Summary Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling
complexes are multi-subunit molecular machines that play vital roles in regulating genomic …
complexes are multi-subunit molecular machines that play vital roles in regulating genomic …
Structure of nucleosome-bound human BAF complex
Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …
SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters
Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more
than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor …
than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor …
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells
The role of individual subunits in the targeting and function of the mammalian BRG1-
associated factors (BAF) complex in embryonic stem cell (ESC) pluripotency maintenance …
associated factors (BAF) complex in embryonic stem cell (ESC) pluripotency maintenance …
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers
S Schick, AF Rendeiro, K Runggatscher, A Ringler… - Nature …, 2019 - nature.com
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF)
chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not …
chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not …
Structure of the RSC complex bound to the nucleosome
The RSC complex remodels chromatin structure and regulates gene transcription. We used
cryo–electron microscopy to determine the structure of yeast RSC bound to the nucleosome …
cryo–electron microscopy to determine the structure of yeast RSC bound to the nucleosome …
SMARCB1-deficient cancers: novel molecular insights and therapeutic vulnerabilities
Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …