Branched-chain amino acids metabolism and their roles in retinopathy: from relevance to mechanism

X Zhang, M Xia, Y Wu, F Zhang - Nutrients, 2023 - mdpi.com
Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide.
Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of …

Advance toward function, production, and delivery of natural astaxanthin: A promising candidate for food ingredients with future perspectives

J Zhang, M Liu, T Han, L Luo, Y Zhang, G Yuan, X Fang… - Food Chemistry, 2024 - Elsevier
Astaxanthin (AST) exhibits potent antioxidant activity, effectively preventing neurological
diseases and cancer. Presently, producing AST from microorganisms like Haematococcus …

Astaxanthin: a marine drug that ameliorates Cerebrovascular-Damage-Associated Alzheimer's disease in a zebrafish model via the inhibition of matrix …

N Paramakrishnan, KG Lim, Y Paramaswaran, N Ali… - Marine Drugs, 2023 - mdpi.com
Alzheimer's disease (AD) is a major type of dementia disorder. Common cognitive changes
occur as a result of cerebrovascular damage (CVD) via the disruption of matrix …

Updates on RPE cell damage in diabetic retinopathy

M Li, M Tian, Y Wang, H Ma… - Molecular …, 2023 - spandidos-publications.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes. The retinal pigment
epithelium (RPE) forms the outer layer of the blood‑retinal barrier and serves a role in …

Astaxanthin inhibits oxidative stress and apoptosis in diabetic retinopathy

J Fang, W Bai, L Yang - Acta Histochemica, 2023 - Elsevier
Background The pathophysiology of diabetic retinopathy (DR) is thought to be influenced by
oxidative stress. Astaxanthin (ASX) is a natural product with antioxidant effect, but it is not …

Qi-Ju-Di-Huang-Pill delays the progression of diabetic retinopathy

C Zhao, G Ma, S Tao, M Wang, Z Chen, Y Fang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Qi-Ju-Di-Huang-Pill (QJDH pill) is a Chinese
decoction. Although it is commonly used to treat eye conditions, such as diabetic retinopathy …

Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products

M Wang, KJ Sheng, JC Fang, H Zhao, SM Lu… - European Journal of …, 2022 - Elsevier
Diabetic retinopathy (DR) is a common serious complication of diabetes that accounts for the
leading cause of blindness among the working-age population in developed countries …

Advance on the effects of algal carotenoids on inflammatory signaling pathways

YD Wang, XR Geng, S Qin, T Che, L Yan… - European Journal of …, 2024 - Elsevier
The development of inflammation has an indispensable importance in the self-protection of
the human body. However, over-inflammation may damage human health, and inflammatory …

Astaxanthin regulates high-carbohydrate diet-induced oxidative stress, inflammation and apoptosis in an organ-specific manner in largemouth bass (Micropterus …

X He, B Chen, Y Chen, A Chen, S Lin, Y Guo, Z Liao… - Aquaculture, 2025 - Elsevier
Largemouth bass (Micropterus salmoides) is widely considered as carbohydrate-intolerant,
and immunological disorders would be induced when fed with high-carbohydrate (HC) diets …

GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice

X Wang, Y Wu, Y Tian, H Hu, Y Zhao, B Xue, Z Sun… - Cell & Bioscience, 2024 - Springer
Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation
involving microglial activation. However, the specific mechanism for microglial activation …