Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly
includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …

Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis.
It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling …

Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal
differentiation of the embryonic kidney. Here we show that overexpression of the …

Lin28, a key factor for cellular reprogramming and generation of induced pluripotent stem
cell (iPSC), makes a critical contribution to tumorigenicity by suppressing Let-7. However, it …

In the human embryo, the genetic program that orchestrates germ cell specification involves
the activation of epigenetic and transcriptional mechanisms that make the germline a unique …

A more complete understanding of aberrant oncogenic signaling in neuroblastoma, a
malignancy of the developing sympathetic nervous system, is paramount to improving …

Management of paediatric extracranial germ-cell tumours carries a unique set of challenges.
Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age …

Knee osteoarthritis (KOA) is a major cause of leg disability in the elderly population.
Recently, the expression levels of circulating microRNA (miRNA) let-7e have been reported …