The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous
membranous network that fulfills multiple homeostatic functions. Among them, it …

Diabetic cardiomyopathy has been reported to increase the risk of fatal ventricular
arrhythmia. The beneficial effects of the selective sodium-glucose cotransporter-2 inhibitor …

Heart failure with preserved ejection fraction (HFpEF) will soon take over as the predominant
form of heart failure. This is largely driven by the continuing increased incidences of obesity …

Intracellular calcium cycling is a vital component of cardiac excitation-contraction coupling.
The key structures responsible for controlling calcium dynamics are the cell membrane …

Calcium (Ca2+) plays a central role in the excitation and contraction of cardiac myocytes.
Experiments have indicated that calcium release is stochastic and regulated locally …

Background/Aims: Resveratrol (Res), a polyphenol antioxidant found in red wine, has been
shown to play a cardioprotective role. This study was undertaken to investigate whether Res …

Background The peculiarities of transverse tubule (T-tubule) morphology and distribution in
the atrium—and how they contribute to excitation-contraction coupling—are just beginning …

Hypothyroidism (Hypo) is a risk factor for cardiovascular diseases, including heart failure.
Hypo rapidly induces Ca 2+ mishandling and contractile dysfunction (CD), as well as …

Aim To determine the CO 2 permeability (PCO 2) of plasma membranes of cardiomyocytes.
These cells were chosen because heart possesses the highest rate of O2 consumption/CO 2 …

Aim Altered organization of the transverse‐tubular network is an early pathological event
occurring even prior to the onset of heart failure. Such t‐tubular remodelling disturbs the …