Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast
Asia and now poses a threat to the control and elimination of malaria. Mapping the …

Understanding transmission biology at an individual level is a key component of intervention
strategies that target the spread of malaria parasites from human to mosquito. Gametocytes …

Achieving malaria elimination requires targeting the human reservoir of infection, including
those with asymptomatic infection. Smear-positive asymptomatic infections detectable by …

Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium
falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the …

Effective anti-malarial drug treatment reduces malaria transmission. This alone can reduce
the incidence and prevalence of malaria, although the effects are greater in areas of low …

Background Artemisinin combination treatments (ACT) are recommended as first line
treatment for falciparum malaria throughout the malaria affected world. We reviewed the …

Malaria transmission requires the production of male and female gametocytes in the human
host followed by fertilization and sporogonic development in the mosquito midgut. Although …

Background Gametocytes are responsible for transmission of malaria from human to
mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte …