Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

New antiparasitic drugs are urgently needed to treat and control diseases such as malaria,
leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year …

The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the
'apicoplast'. The discovery of the apicoplast ushered in an exciting new prospect for drug …

Digested residues from biogas plants are often used as biofertilizers for agricultural crops
cultivation. The antibiotic resistance genes (ARGs) in digested residues pose a high risk to …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Multidrug resistance has rendered monotherapy for malaria useless in most parts of the
world, and has also compromised the usefulness of many of the available combination …

Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …

Malaria remains a significant infectious disease that causes millions of clinical cases and>
800,000 deaths per year. The Malaria Box is a collection of 400 commercially available …

Introduction: Chemotherapy of malaria has become a rapidly changing field. Less than two
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …

It has been demonstrated that fosmidomycin has good tolerability and rapid onset of action,
but late recrudescences preclude its use alone; in vitro, clindamycin has been shown to act …