There is great potential for genome sequencing to enhance patient care through improved
diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential …

The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

Robotics and automation provide potentially paradigm shifting improvements in the way
materials are synthesized and characterized, generating large, complex data sets that are …

Purpose To evaluate the impact of technically challenging variants on the implementation,
validation, and diagnostic yield of commonly used clinical genetic tests. Such variants …

Objective Improving mechanisms to detect adverse drug reactions (ADRs) is key to
strengthening post-marketing drug safety surveillance. Signal detection is presently …

The pace of innovation is accelerating, and so medicines regulators need to actively
innovate regulatory science to protect human and animal health. This requires consideration …

Transporters govern the access of molecules to cells or their exit from cells, thereby
controlling the overall distribution of drugs to their intracellular site of action. Clinically …

ABSTRACT Introduction: Biomedical-engineering (BME) plays a major role in modern
medicine. Many BME-based assets have been brought to clinical translation in the twentieth …

Regulatory science underpins the objective evaluation of medicinal products. It is therefore
imperative that regulatory science and expertise remain at the cutting edge so that …

The need for global regulatory harmonization: A public health imperative | Science Translational
Medicine news careers commentary Journals Science Science brought to you byGoogle Indexer …