Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

INTRODUCTION Glial cells of the central nervous system (CNS), including astrocytes and
microglia, play critical roles in development, tissue repair, and homeostasis. However …

Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

Microglia play key roles in brain development, homeostasis, and function, and it is widely
assumed that the adult population is long lived and maintained by self-renewal. However …

The colony-stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells.
Genetic loss of the CSF1R blocks the normal population of resident microglia in the brain …

Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high
amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic …

Single-cell expression profiling reveals the molecular states of individual cells with
unprecedented detail. Because these methods destroy cells in the process of analysis, they …

Background As core units of organ tissues, cells of various types play their harmonious
rhythms to maintain the homeostasis of the human body. It is essential to identify the …

Monocytes and macrophages provide the first line of defense against pathogens. They also
initiate acquired immunity by processing and presenting antigens and provide the …