DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Recent progress in epigenetics of obesity

FY Wu, RX Yin - Diabetology & Metabolic Syndrome, 2022 - Springer
Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …

Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring

M Denizli, ML Capitano, KL Kua - Frontiers in cellular and infection …, 2022 - frontiersin.org
The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …

The impact of lifestyle, diet and physical activity on epigenetic changes in the offspring—A systematic review

L Rasmussen, S Knorr, CS Antoniussen, JM Bruun… - Nutrients, 2021 - mdpi.com
Aims: This systematic review examines the association between maternal lifestyle, diet and
physical activity, and epigenetic changes in the offspring. Methods: A literature search was …

Molecular pathways in placental-fetal development and disruption

JJ Adibi, Y Zhao, H Koistinen, RT Mitchell… - Molecular and cellular …, 2024 - Elsevier
The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …

Epigenetics as a biomarker for early-life environmental exposure

R Schrott, A Song, C Ladd-Acosta - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review There is interest in evaluating the developmental origins of
health and disease (DOHaD) which emphasizes the role of prenatal and early-life …

Neonatal intensive care admission for term neonates and subsequent childhood mortality: a retrospective linkage study

S Talisman, J Guedalia, R Farkash, T Avitan, N Srebnik… - BMC medicine, 2023 - Springer
Background Neonatal intensive care unit (NICU) admission among term neonates is a rare
event. The aim of this study was to study the association of the NICU admission of term …

Effects of Sex and Obesity on LEP Variant and Leptin Level Associations in Intervertebral Disc Degeneration

HH Chen, HT Hsu, MH Liao, MS Teng - International Journal of Molecular …, 2022 - mdpi.com
Intervertebral disc degeneration (IVDD), for which obesity and genetics are known risk
factors, is a chronic process that alters the structure and function of the intervertebral discs …

Leptin in human milk—one of the key regulators of nutritional programming

E Sinkiewicz-Darol, I Adamczyk, K Łubiech, G Pilarska… - Molecules, 2022 - mdpi.com
Breast milk is the optimal food for infants and toddlers, providing basic nutrients. It is also a
source of many biologically active substances. Among them are hormones responsible for …

Micronutrients throughout the Life Cycle: Needs and Functions in Health and Disease

M Kumar, D Kumar, A Sharma… - Current Nutrition & …, 2024 - ingentaconnect.com
Background: Micronutrients play a vital role in the maintenance and proper functioning of
body tissues. Micronutrients broadly consist of minerals and vitamins. These vitamins and …