Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …

In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …

DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …

Genome maintenance is a constant concern for cells, and a coordinated response to DNA
damage is required to maintain cellular viability and prevent disease. The ataxia …

DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …

Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs)
in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including …

DNA DSBs (double-strand breaks) are considered the most cytotoxic type of DNA lesion.
They can be introduced by external sources such as IR (ionizing radiation), by …

DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …

Preservation of genome integrity via the DNA-damage response is critical to prevent
disease. ATR (ataxia telangiectasia mutated-and Rad3-related) is essential for life and …